Selective Concentration of Human Cancer Cells Using Contactless Dielectrophoresis
Equipment: Plasma Power Supply Systems - Model no. AL-50-HF-A Wideband AC Power Amplifier & Model AL-T350.4 High Frequency Transformer
User: Virginia Tech
Research and Application: Continuous study of contactless dielectrophoresis method of isolating specific cell types from a mixed population of live cells
This paper is a continued study of the contactless dielectrophoresis (cDEP) method used to manipulate and isolate live and dead cells based on their dielectric properties. What makes this paper unique is its demonstration of isolating specific cell types from a mixed population of live cells. Using early, intermediate, and late-stage breast cancer cells, the study identified distinct trapping of frequency responses and successfully isolated late-stage cancer cells at specific voltages and frequencies. This continued research indicates a workbench for clinicians to detect cancerous cells at their earliest stage and possibly eliminate unsuccessful treatment options.
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Erin A. Henslee, Michael B. Sano, Andrea D. Rojas, Eva M. Schmelz, Rafael V. Davalos, et al. “Selective Concentration of Human Cancer Cells Using Contactless Dielectrophoresis.” Electrophoresis, vol. 32, no. 18, Wiley, Aug. 2011, pp. 2523–29
Equipment: Plasma Power Supply Systems - Model no. AL-50-HF-A Wideband AC Power Amplifier & Model AL-T350.4 High Frequency Transformer
User: Virginia Tech
Research and Application: Continuous study of contactless dielectrophoresis method of isolating specific cell types from a mixed population of live cells
This paper is a continued study of the contactless dielectrophoresis (cDEP) method used to manipulate and isolate live and dead cells based on their dielectric properties. What makes this paper unique is its demonstration of isolating specific cell types from a mixed population of live cells. Using early, intermediate, and late-stage breast cancer cells, the study identified distinct trapping of frequency responses and successfully isolated late-stage cancer cells at specific voltages and frequencies. This continued research indicates a workbench for clinicians to detect cancerous cells at their earliest stage and possibly eliminate unsuccessful treatment options.
Read Full Article
Erin A. Henslee, Michael B. Sano, Andrea D. Rojas, Eva M. Schmelz, Rafael V. Davalos, et al. “Selective Concentration of Human Cancer Cells Using Contactless Dielectrophoresis.” Electrophoresis, vol. 32, no. 18, Wiley, Aug. 2011, pp. 2523–29